Lifelong Protection Against Flu? New Vaccine Shows Promise

65-year-old Nebraskan dies from the flu, DHHS advises others to get vaccinated

65-year-old Nebraskan dies from the flu, DHHS advises others to get vaccinated

A 65-year-old in Southeast Nebraska is reportedly the first flu-related death in the state this season, according to the Department of Health and Human Services. It affects a hemagglutinin (HA) protein that occurs in H3N2 viruses.

"The good news is that it's much more hard to drive mutations in the stalk, but it's not impossible", said David J. Topham, the study's author and the Marie Curran Wilson and Joseph Chamberlain Wilson professor in the Department of Microbiology and Immunology at URMC.

New research from Penn's Perelman School of Medicine suggests the low efficacy of the 2016-17 flu shot - about 20 to 30 percent effectiveness, compared to an average of about 50-60 percent - was likely the result of a mutation in the H3N2 strain of the virus. Traditional flu shot basically contains feeble and dead version of flu viruses. They are antigenically similar to the strain of vaccine.

Flu vaccine is available in Pueblo. However, Dr. Vooght explains that the Australia flu situation was severe because it had a mismatch between the vaccine and the virus strain. The eggs are then allowed to incubate, and in turn, this allows the virus to replicate. "It's a virus that spreads quite easily, it's a virus that spreads before any symptoms are even visible". And this is apparently causing problems with the end product.

Disturbance in Caribbean could reach tropical depression status, NHC says
Close proximity to land is likely to limit development of the system during the next 24 hours, forecasters said. Up to five inches of rain is possible in southern Florida, with isolated totals up to eight inches.

Experts worry it could be a hard season if H3N2 dominates. "Here, we biochemically demonstrate that the HA antigenic site B of circulating clade 3C.2a viruses is glycosylated", say the authors. The molecule is a type of sugar, hence the reason it's being called a glycosylation site. That sugar makes its hard for our antibodies to attach to the virus and kill it, and protect the virus from destruction.

"To put this in other terms, our current influenza vaccine programs and technologies reduce influenza infections and hospitalizations by 4.75 percent and 6.9 percent, respectively", Weaver said. It takes two weeks for the flu vaccine to reach maximum protection.

"Our experiments suggest that influenza virus antigens grown in systems other than eggs are more likely to elicit protective antibody responses against H3N2 viruses that are now circulating", Hensley said.

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